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Test One On 2cb 2ce 2ci and Related 2c Series Research Chemicals
2cb 2ce 2ci 2c Series Research Chemicals Test One
Matthew 10:16 Be as wise as a serpent.
(1): True Or False: Phytochemicals are produced BY plants, and "research chemicals" are produced synthetically in a lab by people with DEA licenses that have access to chemicals and solvents that are not available to just anyone.
A) False
B) True
(2): True Or False: There was an operation being run back in the day(until 2012) when these research chemicals were legal, and widely distributed across the U.S. via online vendors including one particular forum called LegalHighGuides.com .
A) True
B) False
(3): True Or False: March 1, 2011, the Drug Enforcement Administration(DEA) used its "emergency scheduling authority" under the CSA(Controlled Substances Act), to ban jwh-018, jwh-073, jwh-200, cp-47, 479, and cannabicyclohexanol into Schedule 1, making their posession and sale illegal.
A) False
B) True
(4): True OR False: A final amendment was added by Senator Dianne Feinstein called s. 3190, titled "A Bill to amend the Constrolled Substance Act to place synthetic drugs in Schedule 1"
A) True
B) False
(5): What does "2c series" refer to?
A) These include research chemicals like: 2c-i, 2c-b, 2c-e, etc, which are synthetic(man-made).
B) It's a television series.
C) It has to do with precursors.
D) They are different types of phytochemicals.
E) None of the above.
(6): True OR False + Fill in the Blank!: 2C-I specifically, is also known as 2,5-dimethoxy-4-iodophenethylamine, is a _______________ of the 2C family that produces ____________ effects
A) True, amphetamine, stimulant
B) False.
C) True, DMT, psychedelic
D) True, phenethylamine, psychedelic
E) None of the above.
(7): The "2c series" of research chemicals were first synthesized by _______________, and is described in Shulgin's book PiHKAL (1991), which ________________ often cited on her Neurosoup operation.
A) Albert hoffman, Krystle cole.
B) Harry potter, Hillary clinton.
C) Alexander Shulgin, Krystle cole.
D) Richard Evans Shultes, Krystle cole.
E) None of the above.
(8): Who is the academic(chemist) that first created MDMA(a form of methamphetamine commonly known as "ecstacy", or "molly").
A) Albert hoffman.
B) Alexander Shulgin
C) Richard Shultes.
D) Terrence Mckenna
E) Dennis Mckenna
(9): These "2c series" of research chemicals were essentially altered versions of already illegal drugs, meant to bypass the law. For example, ________ , a naturally occuring __________ found in insane numbers of legal Cactus and even Acacia species. A lot of legal cactus produce a series of phenethylamines, and __________ is one such compound Note: I originally worded this wrong on my blog. I've sense fixed that.
A) DMT, stimulant, dmt.
B) Ibogaine, psychedelic, ibogaine.
C) Mescaline, psychedelic, mescaline.
D) None of the above.
E) A, B, and C.
(10): Is it safe to say that the "2c series" of research chemicals are pharmaceutical knock off fake versions of the naturally occuring series of chemicals(made by the creator) known as Mescaline and other phenethylamines?
A) Yes, that's exactly what the "2c series" of research chemicals are.
B) No. That's incorrect.
(11): True Or False: Mescaline is produced by cactus and certain plants, and the scientific name for Mescaline is: 3,4,5-Trimethoxyphenethylamine.
A) True
B) False
(12): True Or False: 2c-I Precursors: Its synthesis involves only several steps, starting with commercially available or easily synthesized precursors. Note: Not every substance used to make this stuff is available to the open public, but some are. There may be alternative methods for manufacturing however.
A) True
B) False
(13): Fill in the blanks: Common Precursors for 2C-I and chemicals required to manufacture it: Select ALL that apply.
A) 2,5-Dimethoxybenzaldehyde
B) Nitroethane
C) 2,5-Dimethoxyphenethylamine (2C-H)
D) Iodine, or Iodine-based reagents (ICl, NIS)
E) All of the above.
(14): True Or False: The 2,5-Dimethoxybenzaldehyde precursor is available at walmart.com and amazon.com
A) True
B) False
(15): True OR False: Researchers, Scholars, and people in high places are the ones making these research chemicals, and underground illicit drug labs across the globe. One supplier states in their description: "Nitroethane-1, 1-d2, 1 gram. Price: $522.76. This item can only ship to a Lab or Industrial Facility."(calpaclab.com/nitroethane)
A) True
B) False
(16): True Or False: As far as obtaining 2c-h, only researchers have legal access to it: https://www.caymanchem.com/product/11889/2c-h-(hydrochloride) This means it is illegal to the public but legal to researchers.
A) True
B) False
(17):
A)
B)
C)
D)
E)
(18): True Or False + Fill in the blank. Scientist have conducted studies to evaluate the neurotoxicity of psychoactive abused 2,5-dimethoxy-substituted phenethylamines "2C series" in monoaminergic neurons. The results showed that: _________________________________________________
A) "These substances displayed remarkable safety, being far more safe than naturally occuring illegal drugs produced by plants"
B) "The '2C series'-induced neurotoxicity in both cells was higher than that of MDMA or METH (EC50: ≥ 1–2 mM)."
C) "The substances in the 2c series displayed no harmful or neurotoxic effects in rat subjects."
D) None of the above.
(19): True OR False: "The 2,5-dimethoxy-substitution of '2C series' induced severe neurotoxicity in both dopaminergic and serotonin-containing neurons."
A) False
B) True
(20): True Or False: When researchers compared 25i-NBOMe with 2C-I, which are often confused for one another, studies show that 25I-NBOMe is more cytotoxic than 2C-I, likely due to its higher lipophilicity.
A) True, 25i-nbome is worse for you than 2c-i.
B) False.
(21): True Or False: Both drugs induce mitochondrial dysfunction, and 2C-I induces autophagy and caspase-3 activation. Finally, apoptosis was identified as a mechanism of cell death induced by both drugs.
A) False
B) True
(22): Fill in the blank: 2C-T-7 is generally consumed orally, and it produces ________ and _________ effects that last 8 to 15 hours
A) psychedelic and entactogenic
B) stimulant and empathogenic
C) sedative and oneirogenic
D) opioid and psychedelic
E) none of the above.
(23): True Or False: Because it is a fake version of the God-made naturally recurring phytochemical known as Mescaline(a type of phenethylamine), it is often sold and mismarketed as Mescaline, a dangerous lie.
A) True
B) False
(24): 2C-T-7 often goes by the slang names of: ______ and ______
A) "Blue Mystic", and "7th Heaven"
B) "Hell crystals", and "The Devils Quartz"
C) "Satans Jewels", and "Lucifers Diamonds"
D) "Yellow Chards", and "Turf Surf"
E) None of the above.
(25): What are some slang names for 2c-b? (street names) Select ALL that apply
A) Bromo-Mescaline
B) "Bee's"
C) Nexus
D) Venus
E) All of the above.
(26): True Or False: 2c-H is a research chemical that researchers have access to, and it can be used to illegally manufacture 2c-i, 2c-b, etc. Not just anyone can get their hands on it legally, but researchers can. (IE "Controlled Substance")
A) True, just because something is controlled doesn't mean researchers don't have access to it legally, because they do.
B) Nah that's b.s.
(27): True Or False: Alexander shulgin, the famous chemist/scholar gives instructions in his book on how to synthesize these "2c series" of drugs. (Shulgin, A., & Shulgin, A. (1991). PIHKAL: A Chemical Love Story.)
A) True
B) False
Answer key:
1) True, B.
2) True, A.
3) True, B.
4) True, A.
5) A
6) D
7) C
8) B
9) C
10) A
11) True, A.
12) True, A.
13) E, or A B C & D
14) True, A.
15) True, A.
16) True, A.
17)
18) B
19) True, B.
20) True, A.
21) True, B.
22) A.
23) True, A.
24) A
25) E, or A B C D
26) A, True.
27) True, A.
Academic citations:
[1] https://www.dea.gov/press-releases/2011/03/01/chemicals-used-spice-and-k2-type-products-now-under-federal-control-and
[3] https://www.congress.gov/bill/112th-congress/senate-bill/3190/text
[4] PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Mescaline
[6] https://www.researchgate.net/publication/362092518_PHENYLETHYLAMINE_HEALTH_BENEFITS_-A_REVIEW
[7] Halberstadt, Adam L., and Mark A. Geyer. "Effects of the hallucinogen 2, 5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response." Neuropharmacology 77 (2014): 200-207.
[9] Mitchell, Jennifer M. "A Psychedelic for Trauma." Scientific American 326 (2022): 56-61.
[10] Academic sources cited on blog: Acacia berlandieri plant profile
[11] https://scilearn.sydney.edu.au/firstyear/exams/chem1611/2003answers/2003-N-4.pdf
[12] Seminal text by the discoverer of 2C-I, detailing synthesis routes for 2C compounds. https://erowid.org/library/books_online/pihkal/pihkal.shtml
[13] Casale, J.F., Hays, P.A., & Spratley, T.A. (2005). "Characterization and differentiation of substituted phenethylamines by GC-MS and NMR." Forensic Science International, 149(2-3), 181-188.
[14] Kufner, H., Westphal, F., & Weber, A.A. (2005). "Studies on the synthesis and mass spectrometric behavior of 2C hallucinogenic phenethylamines." Archiv für Kriminologie, 216, 1–2.
[15] EMCDDA (European Monitoring Centre for Drugs and Drug Addiction) – "Report on the risk assessment of 2C-I in the framework of the joint action on new synthetic drugs."
[16] UNODC: "Recommended methods for the identification and analysis of amphetamine, methamphetamine and their ring-substituted analogues in seized materials" (2006).
[17] United Nations: https://www.unodc.org/pdf/scientific/STNAR34.pdf
[18] Asanuma, Masato, Ikuko Miyazaki, and Masahiko Funada. "The neurotoxicity of psychoactive phenethylamines “2C series” in cultured monoaminergic neuronal cell lines." Forensic Toxicology 38 (2020): 394-408.
[19] Gil-Martins, Eva, et al. "The Role of Mitochondrial Dysfunction and Calcium Dysregulation in 2C-I and 25I-NBOMe-Induced Neurotoxicity." Chemico-Biological Interactions (2025): 111425.
[20] https://medschool.ucla.edu/news-article/mitochondria-function-form-and-food
[21] National Library Of Medicine: Cellular and molecular mechanisms of mitochondrial function Laura D Osellame a,b,d, Thomas S Blacker a,c,d, Michael R Duchen a,b,∗ PMCID: PMC3513836 PMID: 23168274 https://pmc.ncbi.nlm.nih.gov/articles/PMC3513836/
[22] Ermakova, Anna O., et al. "A narrative synthesis of research with 5-MeO-DMT." Journal of Psychopharmacology 36.3 (2022): 273-294.
Psyched Substances:
[5] Psyched-Substances Review: 2c-b
[9] Brandt, Simon D., et al. (2004). "Synthesis, structure elucidation and analytical properties of 2C-B." Journal of Pharmaceutical and Biomedical Analysis 36.4 (2004): 825–833. DOI: 10.1016/j.jpba.2004.08.011
[10] Backes, G., & Dye, D. (2004). “Synthesis and characterization of the phenethylamines: 2C-B and 2C-I.†Microgram Journal, 2(1-2), 15–23.
[8] Shulgin, Alexander, and Ann Shulgin. PiHKAL. Synergetic Press, 2021.
[24] Balick, Michael J., and Paul Alan Cox. Plants, People, and Culture : The Science Of Ethnobotany. New York, Garland Science, 2020.
[25] Swerdlow, Joel L. Nature's Medicine : Plants That Heal. Washington, D.c., National Geographic Society, 2000.
[26] Tyler, Varro E, et al. Pharmacognosy. 1988.
[23] Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. 2C-N Entry in PiHKAL
Encyclopedia Sources:
[2] https://en.m.wikipedia.org/wiki/JWH-018
Other resources:
M.A.P.S. Ethnobotanical Studies By Scholars
National Library Of Medicine https://www.nlm.nih.gov/
PubChem - pubchem.ncbi.nlm.nih.gov